PETER THIEL: "Andrew Wiles demonstrated this when he proved Fermat’s Last Theorem after 358 years of fruitless inquiry by other mathematicians— the kind of sustained failure that might have suggested an inherently impossible task. Pierre de Fermat had conjectured in 1637 that no integers a, b, and c could satisfy the equation an + bn = cn for any integer n greater than 2. He claimed to have a proof, but he died without writing it down, so his conjecture long remained a major unsolved problem in mathematics. Wiles started working on it in 1986, but he kept it a secret until 1993, when he knew he was nearing a solution. After nine years of hard work, Wiles proved the conjecture in 1995. He needed brilliance to succeed, but he also needed a faith in secrets. If you think something hard is impossible, you’ll never even start trying to achieve it. Belief in secrets is an effective truth. "The actual truth is that there are many more secrets left to find, but they will yield only to relentless searchers. There is more to do in science, medicine, engineering, and in technology of all kinds. We are within reach not just of marginal goals set at the competitive edge of today’s conventional disciplines, but of ambitions so great that even the boldest minds of the Scientific Revolution hesitated to announce them directly. We could cure cancer, dementia, and all the diseases of age and metabolic decay. We can find new ways to generate energy that free the world from conflict over fossil fuels. We can invent faster ways to travel from place to place over the surface of the planet; we can even learn how to escape it entirely and settle new frontiers. But we will never learn any of these secrets unless we demand to know them and force ourselves to look." — Peter Thiel, Zero to One (2014)